<i>Trans</i>-palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different mechanism from the <i>cis</i> isomer
Eliza Korkus, Marcin Szustak, Rafał Madaj, Arkadiusz Chworoś, Anna Drzazga, Maria Koziołkiewicz, Grzegorz Dąbrowski, Sylwester Czaplicki, Iwona Konopka, Edyta Gendaszewska‐Darmach
Abstract
Trans - and cis palmitoleic acids stimulate insulin secretion from pancreatic β cells with a similar potency. Both isomers activate GPR40, GPR55, GPR119, and GPR120 receptors with similar potency but with activation of different signaling pathways.
Topics & Concepts
Free fatty acid receptor 1Palmitoleic acidPotencyGPR120ReceptorChemistrySecretionInsulinEndocrinologySignal transductionInternal medicineAgonistBiochemistryG protein-coupled receptorBiologyPalmitic acidFatty acidMedicineIn vitroDiabetes Treatment and ManagementPancreatic function and diabetesCholesterol and Lipid Metabolism