BAY11-7082 Targets RNF25 to Reverse TRIP4 Ubiquitination-dependent NF-κB Activation and Apoptosis Resistance in Renal Cell Carcinoma
Lei Li, Zixi Wang, Bohan Ma, Qi Ye, Yuzeshi Lei, Mingming Lu, Leihong Ye, Jialu Kang, Wenyue Huang, Shan Xu, Ke Wang, Yule Chen, Jing Liu, Yang Gao, Chenji Wang, Jian Ma, Lei Li
Abstract
). We further demonstrate that the NF-κB inhibitor BAY11-7082 directly interacts with RNF25, reversing its pro-survival effects and restoring apoptosis sensitivity. Our findings establish RNF25 as a druggable orchestrator of therapy resistance through NF-κB pathway modulation and propose pharmacological targeting of RNF25 by BAY11-7082 as a strategy to overcome apoptosis resistance in renal malignancies.
Topics & Concepts
ApoptosisUbiquitinCancer researchNF-κBRenal cell carcinomaNFKB1BiologyCell biologyMedicineInternal medicineGeneticsTranscription factorGeneCancer Mechanisms and TherapyBladder and Urothelial Cancer TreatmentsUbiquitin and proteasome pathways