Decarboxylative Enamide Synthesis from Carboxylic Acid and Alkenyl Isocyanate
Rui Wang, Wenbo Liu
Abstract
Herein, we reported a protocol to access the enamide via employing carboxylic acid and alkenyl isocyanate as the precursors promoted by DMAP without involving any metal catalysts and dehydration reagents. This protocol is simple and practical and tolerates numerous functional groups. Considering the simplicity, the ready availability of both starting materials, and the significance of the enamides, we expect that this reaction will find broad application.
Topics & Concepts
ChemistryIsocyanateReagentCarboxylic acidCatalysisCombinatorial chemistryProtocol (science)Organic chemistrySimplicityDehydrationReaction conditionsBiochemistryPathologyEpistemologyPolyurethaneMedicinePhilosophyAlternative medicineAdvanced Synthetic Organic ChemistryChemical Synthesis and AnalysisSynthesis and Catalytic Reactions