Isothiourea-Catalyzed [2 + 2] Cycloaddition of C(1)-Ammonium Enolates and <i>N</i>-Alkyl Isatins
Yusra Abdelhamid, Kevin Kasten, Joanne Dunne, Will C. Hartley, Claire M. Young, David B. Cordes, Alexandra M. Z. Slawin, Sean Ng, Andrew D. Smith
Abstract
ring opening with an amine nucleophile generates isolable highly enantioenriched products in up to 92:8 dr and in >99:1 er.
Topics & Concepts
ChemistryCycloadditionAlkylNucleophileAmmoniumCatalysisEnantioselective synthesisRing (chemistry)Amine gas treatingMedicinal chemistryOrganic chemistryAsymmetric Synthesis and CatalysisFluorine in Organic ChemistryCyclopropane Reaction Mechanisms