L1 drives IFN in senescent cells and promotes age-associated inflammation
Marco De Cecco, Takahiro Ito, Anna P. Petrashen, Amy E. Elias, Nicholas Skvir, Steven W. Criscione, Alberto Caligiana, Greta Brocculi, Emily M. Adney, Jef D. Boeke, Oanh Lê, Christian Beauséjour, Jayakrishna Ambati, Kameshwari Ambati, Matthew Simon, Andrei Seluanov, Vera Gorbunova, P. Eline Slagboom, Stephen L. Helfand, Nicola Neretti, John M. Sedivy
Topics & Concepts
Reverse transcriptaseRetrotransposonBiologySenescenceInflammationInterferonPhenotypeAgeingNucleoside Reverse Transcriptase InhibitorImmunologyCell biologyRNAGeneticsGeneGenomeTransposable elementChromosomal and Genetic VariationsCytomegalovirus and herpesvirus researchinterferon and immune responses