Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review
Wen-Rui He, Jin Yuan, Yuhe Ma, Cheng-Yan Zhao, Zhongyuan Yang, Yuhang Zhang, Shichong Han, Bo Wan, Gaiping Zhang
Abstract
African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and fatal disease found in swine. However, the viral proteins and mechanisms responsible for immune evasion are poorly understood, which has severely hindered the development of vaccines. This review mainly focuses on studies involving the innate antiviral immune response of the host and summarizes the latest studies on ASFV genes involved in interferon (IFN) signaling and inflammatory responses. We analyzed the effects of candidate viral proteins on ASFV infection, replication and pathogenicity and identified potential molecular targets for novel ASFV vaccines. These efforts will contribute to the construction of novel vaccines and wonder therapeutics for ASF.