Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling
Yuanyuan Hao, Panpan Chen, Shanshan Guo, Mengyuan Li, Xueli Jin, Minghuan Zhang, Wenhai Deng, Ping Li, Wen Lei, Aibin Liang, Wenbin Qian
Topics & Concepts
Chimeric antigen receptorCancer researchMicrovesiclesCD19T cellBiologyImmune systemImmunologymicroRNAGeneBiochemistryCAR-T cell therapy researchSilicon Carbide Semiconductor TechnologiesNanowire Synthesis and Applications