No renal dysfunction or salt and water retention in acute mountain sickness at 4,559 m among young resting males after passive ascent
Jérôme Biollaz, Thierry Buclin, Wulf Hildebrandt, Laurent A. Décosterd, Jürg Nussberger, Erik R. Swenson, Peter Bärtsch
Abstract
Kidney function remained essentially unaffected and acute mountain sickness (AMS) was not associated with salt and water retention in healthy young men flown to and resting at the Margherita hut (4,559 m) under strictly controlled conditions maintaining water, salt, and food intake at pre-exposure levels. Thus, renal dysfunction and fluid retention are not essential factors contributing to the pathophysiology of AMS.
Topics & Concepts
PathophysiologyMedicineRenal functionInternal medicineAcute exposureWater retentionFluid intakePhysiologyCardiologyEndocrinologyBiologyEcologySoil waterHigh Altitude and HypoxiaClimate Change and Health ImpactsThermoregulation and physiological responses