Interfacing metal-polyphenolic networks upon photothermal gold nanorods for triplex-evolved biocompatible bactericidal activity
Cuiyun Zhang, Lunjie Huang, Da‐Wen Sun, Hongbin Pu
Abstract
Gold nanorods (GNRs) outstand in photothermal disinfection but are faced with severe surface chemistry and dose relevant biotoxicity. Herein, a naturally green building block, metal-phenolic networks (MPNs), was employed to functionalize GNRs via coordination reaction, yielding a tunable and biocompatible core-shell photothermal nano-bactericide (GNRs@MPNs). The bioactive GNRs@MPNs built with iron and polyphenols (tannic acid, epigallocatechin gallate, and procyanidins) exhibited superior light-to-heat conversion efficiencies with η = 29.29-44.00%, remarkably preceding that of GNRs (η = 12.24%), which could rapidly ablate 99.8% of Escherichia coli O157: H7 and 98.6% of Staphylococcus aureus bacteria in relatively low efficacy doses (10 ppm of Au). Moreover, local heat triggered by GNRs@MPNs accelerated the healing of the cutaneous wound of a mice model infected by methicillin-resistant S. aureus. The facile synthesis, photothermal synergy, polyphenolic bioactivity, and significantly low efficacy dose of GNRs@MPNs empower them satisfactory efficiency and biosafety in the future broad-spectrum photothermal sterilization applications.