One-Pot Assembly of 3-Hydroxycarbazoles via Uninterrupted Propargylation/Hydroxylative Benzannulation Reactions
Chada Raji Reddy, Muppidi Subbarao, Puppala Sathish, Dattahari H. Kolgave, Ramachandra Reddy Donthiri
Abstract
A novel strategy for the synthesis of 3-hydroxycarbazoles involving the consecutive propargylation/palladium-catalyzed hydroxylative benzannulation of indole-2-carbonyls with propargylic alcohols has been exploited. This one-pot procedure leads to a wide range of substituted 3-hydroxycarbazoles in high yield with a broad substrate scope. The method was further extended to access furano-carbazole derivatives from dialkynols via tandem annulations.
Topics & Concepts
ChemistryCarbazoleTandemYield (engineering)Indole testCatalysisCombinatorial chemistrySubstrate (aquarium)PalladiumAnnulationScope (computer science)Organic chemistryOceanographyComposite materialGeologyProgramming languageMaterials scienceMetallurgyComputer scienceCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsSynthesis of Indole Derivatives