FOXA1 Regulation Turns Benzamide HDACi Treatment Effect-Specific in BC, Promoting NIS Gene-Mediated Targeted Radioiodine Therapy
Maitreyi Rathod, Madhura Kelkar, Snehal K. Valvi, Girish Salve, Abhijit De
Abstract
I in MS-275-treated tumors. Thus, bHDACi-mediated selective enhancement ensuring minimal off-target effect is a step further toward using NIS as a therapeutic target for BC.
Topics & Concepts
Sodium-iodide symporterCancer researchClonogenic assayBenzamideHistone deacetylaseThyroid cancerSymporterChemistryFOXA1Breast cancerMedicineCancerInternal medicineGeneApoptosisHistoneBiochemistryTransporterOrganic chemistryThyroid Cancer Diagnosis and TreatmentHistone Deacetylase Inhibitors ResearchCancer-related gene regulation