Sigma–1 receptor activation alleviates blood–brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF–GFRα1–RET pathway
Danyang Liu, Luxi Yang, Peng Liu, Xuefei Ji, Xiaoxiao Qi, Ziqi Wang, Tianyan Chi, Libo Zou
Topics & Concepts
Glial cell line-derived neurotrophic factorNeuroscienceMedicineStroke (engine)IschemiaBlood–brain barrierSigma-1 receptorBrain ischemiaReceptorInternal medicineCentral nervous systemPsychologyNeurotrophic factorsPhysicsAgonistThermodynamicsPharmacological Receptor Mechanisms and EffectsNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling