Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum
Caitlin A. Brennan, Geicho Nakatsu, Carey Ann Gallini Comeau, David A. Drew, Jonathan N. Glickman, Robert E. Schoen, Andrew T. Chan, Wendy S. Garrett
Abstract
There is an increasing understanding of the clinical correlations and potential mechanistic roles of specific members of the gut and tumoral microbiota in colorectal cancer (CRC) initiation, progression, and survival. However, we have yet to parlay this knowledge into better CRC outcomes through microbially informed diagnostic, preventive, or therapeutic approaches.
Topics & Concepts
Fusobacterium nucleatumColorectal cancerAspirinMedicineCancerFusobacteriumGut floraBioinformaticsCancer researchInternal medicineImmunologyBiologyBacteriaBacteroidesGeneticsPorphyromonas gingivalisPeriodontitisGut microbiota and healthHelicobacter pylori-related gastroenterology studiesClostridium difficile and Clostridium perfringens research