<i>In situ</i> tuning proangiogenic factor-mediated immunotolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor
Chen Chen, Shengchang Zhang, Rui Zhang, Peng Sun, Chongdeng Shi, Mohnad Abdalla, Anning Li, Jiawen Xu, Wei Du, Jing Zhang, Ying Liu, Chunwei Tang, Zhenmei Yang, Xinyi Jiang
Abstract
Our work provides an alternative strategy for exerting efficient tumoricidal immunity in the proangiogenic factor-upregulated subpopulation of CRC patients and may have a wide-ranging impact on cancer immune-anti-angiogenic complementary therapy in clinics.
Topics & Concepts
NanoreactorHypoxia (environmental)LiposomePharmacologyImmunityMedicineImmune systemChemistryImmunologyBiochemistryOxygenOrganic chemistryCatalysisNanoplatforms for cancer theranosticsCancer Research and TreatmentsImmune cells in cancer