A synergistic chemodynamic–photodynamic-photothermal therapy platform based on biodegradable Ce-doped MoO<sub><i>x</i></sub>nanoparticles
Danyang Li, Enna Ha, Jingge Zhang, Luyang Wang, Junqing Hu
Abstract
) and glutathione (GSH) is boosted which enhances the chemodynamic and photodynamic therapy simultaneously. Under NIR II laser irradiation, the designed CMO nanocatalysts induce metabolism disruption and mitochondrial damage in the tumor cells. As-prepared CMO nanomaterials also show good biocompatibility and pH-responsive degradation behavior, which can be degraded rapidly under alkaline conditions (pH = 7.4) and remain stable in acidic solution (pH = 5.6). These properties make CMO nanomaterials ideal biodegradable nanotheranostic agents for synergistic chemodynamic-photodynamic-photothermal antitumor therapy.
Topics & Concepts
Photothermal therapyNanomaterialsBiocompatibilityCatalysisHydrogen peroxideChemistryNanoparticleCeriumNanotechnologyDopingMaterials scienceNanomaterial-based catalystPhotodynamic therapyLanthanidePhotochemistryInorganic chemistryBiochemistryOrganic chemistryIonOptoelectronicsAdvanced Nanomaterials in CatalysisNanoplatforms for cancer theranosticsAdvanced Photocatalysis Techniques