FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts
Liankang Sun, Yue Li, Hao Wang, Xuelian Xiao, Xuenan Luo, Ruida Yang, Jinyan Li, Yifei Ma, Qingguang Liu, Kangsheng Tu, Yu Shi
Abstract
shRNA as an effective strategy that targets FOXC2 leading to the resolution of liver fibrosis.
Topics & Concepts
Hepatic stellate cellGene knockdownDownregulation and upregulationCell biologyCancer researchFibrosisChemistryBiologyCell cultureMedicineGeneInternal medicineEndocrinologyBiochemistryGeneticsLiver physiology and pathologyLiver Disease Diagnosis and TreatmentFOXO transcription factor regulation