Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles
Kenneth W. Witwer, Deborah C. I. Goberdhan, Lorraine O’Driscoll, Clotilde Théry, Joshua A Welsh, Cherie Blenkiron, Edit I. Buzás, Dolores Di Vizio, Uta Erdbrügger, Juan Manuel Falcón‐Pérez, Qing‐Ling Fu, Andrew F. Hill, Metka Lenassi, Jan Lötvall, Rienk Nieuwland, Takahiro Ochiya, Sophie Rome, Susmita Sahoo, Lei Zheng
Abstract
The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was informed by input from more than 400 scientists and made recommendations in the six broad topics of EV nomenclature, sample collection and pre-processing, EV separation and concentration, characterization, functional studies, and reporting requirements/exceptions. To gather opinions on MISEV and ideas for new updates, the ISEV Board of Directors canvassed previous MISEV authors and society members. Here, we share conclusions that are relevant to the ongoing evolution of the MISEV initiative and other ISEV rigour and standardization efforts.