Autophagy controls neuronal differentiation by regulating the WNT-DVL signaling pathway
Vincencius Vidyawan, Lesly Puspita, Virginia Blessy Juwono, Magdalena Deline, Kelvin Pieknell, Mi‐Yoon Chang, Sang‐Hun Lee, Jaewon Shim
Abstract
: BafA1: bafilomycin A1; co-IP: co-immunoprecipitation; DVL2: dishevelled segment polarity protein 2; EPG5: ectopic P-granules 5 autophagy tethering factor; gRNA, guide RNA; hESC: human embryonic stem cells; KO: knockout; mDA, midbrain dopamine; NIM: neural induction media; NPC: neuronal progenitor cell; qPCR: quantitative polymerase chain reaction; UPS: ubiquitin-proteasome system; WNT: Wnt family member; WT: wild type.
Topics & Concepts
BiologyAutophagyWnt signaling pathwayCell biologySignal transductionNeuroscienceGeneticsApoptosisAutophagy in Disease and TherapyCancer-related gene regulationNuclear Receptors and Signaling