Effect of endothelial glycocalyx on water and LDL transport through the rat abdominal aorta
Hongyan Kang, Jiali Yang, Weichen Zhang, Jinyan Lu, Xuejiao Ma, Anqiang Sun, Xiaoyan Deng
Abstract
A 42% degradation of the endothelial glycocalyx by hyaluronidase of the isolated rat abdominal aorta facilitated water and LDL transport across the vessel wall, suggesting endothelial glycocalyx as a transport barrier. A 24-h shear exposure increased LDL mean maximum infiltration distance, and enhanced EC apoptosis, which could be both inhibited by hyaluronidase treatment, suggesting endothelial glycocalyx may also act as a mechanosensor of shear to regulate EC apoptosis, thus affecting leaky junctions and regulating LDL transport.
Topics & Concepts
GlycocalyxChemistryAbdominal aortaHyaluronidaseCell biologyApoptosisEndothelial stem cellBiophysicsAortaInternal medicineBiologyBiochemistryMedicineIn vitroEnzymeTrauma, Hemostasis, Coagulopathy, ResuscitationChronic Kidney Disease and DiabetesTraumatic Brain Injury and Neurovascular Disturbances