Cereblon modulator CC-885 induces CRBN-dependent ubiquitination and degradation of CDK4 in multiple myeloma
Min Zhao, Min Hu, Yong Chen, Heyi Liu, Yulu Chen, Bin Liu, Baijun Fang
Topics & Concepts
CereblonUbiquitinUbiquitin ligaseCancer researchCytotoxicityChemistryCell biologyCell cycle checkpointProtein degradationCell cycleIn vitroBiologyCellBiochemistryGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways