Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes HIV-1 Replication through Modulating microRNAs in Macrophages
Zhihong Yuan, Yunlong Huang, Ruxana T. Sadikot
Abstract
Viral reservoirs constitute an obstacle to curing HIV-1 diseases, despite antiretroviral therapy. Macrophages serve as viral reservoirs in HIV infection by promoting long-term replication and latency. Recent studies have shown that lncRNAs can modulate virus-host interactions, but the underlying mechanisms are not fully understood. In this study, we demonstrate how lncRNA MALAT1 contributes to HIV-1 replication through modulation of the miR-150/SOCS1 axis in human macrophages. Our findings have the potential to identify new therapies for eliminating HIV-1 reservoirs in immune cells.
Topics & Concepts
BiologyMALAT1Suppressor of cytokine signaling 1microRNALong non-coding RNAProinflammatory cytokineCancer researchViral replicationCytokineDownregulation and upregulationVirologyImmunologyVirusGeneInflammationSuppressorGeneticsCancer-related molecular mechanisms researchMicroRNA in disease regulationRNA modifications and cancer