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A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy

Zaizhou Liu, Kaige Chen, Jun Dai, Peng Xu, Wei Sun, Wanlin Liu, Zhixin Zhao, Steven Bennett, Peifeng Li, Tiancheng Ma, Yuqi Lin, Akinori Kawakami, Jing Yu, Fei Wang, Handong Wang, Miao Li, Peter Chase, Peter Hodder, Timothy Spicer, Louis Scampavia, Chunyang Cao, Lifeng Pan, Jiajia Dong, Yong Chen, Biao Yu, Min Guo, Pengfei Fang, David E. Fisher, Jing Wang

2023Cell Research21 citationsDOIOpen Access PDF

Topics & Concepts

Microphthalmia-associated transcription factorMelanomaCancer researchIRF4Transcription factorBiologyCell biologyChemistryGeneticsGenemelanin and skin pigmentationMast cells and histamineRNA regulation and disease
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy | Litcius