N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization
Chen Chen, Weitang Yuan, Quanbo Zhou, Bo Shao, Yuying Guo, Weiwei Wang, Shuaixi Yang, Yaxin Guo, Luyang Zhao, Qin Dang, Xiuxiu Yang, Guixian Wang, Qiaozhen Kang, Zhenyu Ji, Jinbo Liu, Zhenqiang Sun
Abstract
METTL3-induced circ1662 promoted CRC cell invasion and migration by accelerating YAP1 nuclear transport. This result implies that circ1662 is a new prognostic and therapeutic marker for CRC metastasis.
Topics & Concepts
Colorectal cancerYAP1MetastasisCancer researchCancerMedicineChemistryInternal medicineBiochemistryTranscription factorGeneCircular RNAs in diseasesRNA Research and SplicingMicroRNA in disease regulation