CRISPR/Cas12a-mediated electrochemiluminescence platform for environmental and human serum SARS-CoV-2 RNA monitoring using a self-enhanced ruthenium complex linked to zeolitic imidazole framework-8
Fan Yang, Wei Wang, Mei Zhang, Wenxin Tao, Youwang Wang, Jiameng Shi, Yuedi Ding, Minhao Xie, Sai Zhang, Zhenqiang Fan, Kai Zhang
Abstract
Monitoring of SARS-CoV-2 RNA using self-enhancing ruthenium compounds attached to ZIF-8 and CRISPR–Cas12a trans -cleavage properties.
Topics & Concepts
RutheniumCRISPRImidazoleElectrochemiluminescenceRNAChemistryCombinatorial chemistryComputational biologyBiochemistryBiologyCatalysisGeneChromatographyDetection limitAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testingBiosensors and Analytical Detection