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Berbamine targets the FKBP12-rapamycin-binding (FRB) domain of the mTOR complex to promote microglial autophagy and ameliorate neuroinflammation in Alzheimer’s disease

Pingyuan Ge, Siqi Guo, Pingping Wang, Peng Zhou, Zhishu Tang, Nian‐Yun Yang, Rui Guo, Qingqing Xiao, Xin Chai, Qichun Zhang, Huaxu Zhu

2025Phytomedicine8 citationsDOI

Topics & Concepts

NeuroinflammationAutophagyPI3K/AKT/mTOR pathwayFKBPNeuroscienceMicrogliaCell biologyCancer researchDiseaseChemistryBiologyMedicineSignal transductionApoptosisImmunologyInflammationInternal medicineBiochemistryBerberine and alkaloids researchAlzheimer's disease research and treatmentsAlkaloids: synthesis and pharmacology
Berbamine targets the FKBP12-rapamycin-binding (FRB) domain of the mTOR complex to promote microglial autophagy and ameliorate neuroinflammation in Alzheimer’s disease | Litcius