AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research
Hallvard Lauritz Olsvik, Terje Johansen
Abstract
In this issue of PLOS Biology, Ibrahim and colleagues demonstrate how AlphaFold-multimer, an artificial intelligence-based structure prediction tool, can be used to identify sequence motifs binding to the ATG8 family of proteins central to autophagy.
Topics & Concepts
BiologyATG8AutophagyComputational biologySequence (biology)Sequence motifGeneticsCell biologyGeneApoptosisAutophagy in Disease and TherapyRNA modifications and cancerCancer-related gene regulation