Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis
Chengyu Yin, Qianqian Lyu, Zishan Dong, Boyu Liu, Keke Zhang, Zhende Liu, Qìng Yu, Peiyi Li, Zhuoqun Wei, Yan Tai, Chuan Wang, Jianqiao Fang, Weizhi Liu, Boyi Liu
Abstract
AOS3 ameliorates gouty arthritis via activating Nrf2-dependent antioxidant signaling, resulting in suppression of ROS-mediated NLRP3 inflammasome activation and TRPV1 enhancement. AOS3 may be novel therapeutics for gouty arthritis.
Topics & Concepts
InflammationGouty arthritisArthritisMedicineJoint painJoint (building)ImmunologyInternal medicineEngineeringArchitectural engineeringGout, Hyperuricemia, Uric AcidPharmacological Effects of Natural CompoundsInflammasome and immune disorders