The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions
Meng Zhao, Shuyun Liu, Yizhuo Wang, Ke Lv, Peng Lou, Pingya Zhou, Jia‐Ying Zhu, Lan Li, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Abstract
This study identified the critical role of the mitochondria‒paraspeckle axis in regulating cell survival and may provide insights into developing advanced stem cell therapies for tissue engineering and regenerative medicine.
Topics & Concepts
TFAMOxidative stressCell biologyStem cellMitochondrionBiologyApoptosisMesenchymal stem cellDNA damageSenescenceProgrammed cell deathMitochondrial DNACancer researchGeneticsMitochondrial biogenesisEndocrinologyDNAGeneAutophagy in Disease and TherapyMitochondrial Function and PathologyCancer-related molecular mechanisms research