Physiological determinants of decreased peak leg oxygen uptake in chronic disease: a systematic review and meta-analysis
Stephen Foulkes, Peter D. Wagner, Jing Wang, André La Gerche, Mark J. Haykowsky
Abstract
Peripheral (skeletal muscle and vasculature) factors contribute significantly to reduced exercise capacity during both large and small muscle mass exercise in chronic diseases such as COPD, HFrEF, or RF and should be important targets of therapy in addition to the primary organs (lungs, heart, and kidneys) affected by disease.
Topics & Concepts
COPDMedicineCardiologyInternal medicineMeta-analysisVO2 maxCardiorespiratory fitnessHeart failureOxygen transportApparent oxygen utilisationEjection fractionOxygenHeart rateChemistryBlood pressureOrganic chemistryCardiovascular and exercise physiologyStroke Rehabilitation and RecoveryChronic Obstructive Pulmonary Disease (COPD) Research