Synthesis and Anthelmintic Activity of New Thiosemicarbazide Derivatives—A Preliminary Study
Katarzyna Dziduch, Przemysław Kołodziej, Agata Paneth, Anna Bogucka‐Kocka, Monika Wujec
Abstract
Parasitic infections caused by different species of intestinal helminths still poses a threat to public health. There is a need to search for new, effective anthelmintic drugs. A series of novel thiosemicarbazides were synthesized and evaluated for their in vitro anthelmintic activity. The preliminary results showed that the most of synthesized compounds were very active. 4-Phenyl-1-[(1-methyl-4-nitroimidazol-2-yl)carbonyl]thiosemicarbazide and 4-(3-chlorophenyl)-1-[(1-methyl-4-nitroimidazol-2-yl)carbonyl]thiosemicarbazide showed a 100% mortality of nematodes and a high anthelmintic activity in both tested concentrations.
Topics & Concepts
AnthelminticIn vitroChemistryHelminthsPharmacologyTraditional medicineMedicineImmunologyBiochemistryVeterinary medicineParasites and Host InteractionsHelminth infection and controlPhenothiazines and Benzothiazines Synthesis and Activities