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Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and SAR studies

Rana T. Diab, Zakaria K. Abdel-Sami, Eatedal H. Abdel‐Aal, Ahmed A. Al‐Karmalawy, Nader E. Abo‐Dya

2021New Journal of Chemistry31 citationsDOI

Abstract

Novel oxadiazole candidates as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and sar studie.

Topics & Concepts

ChemistryDocking (animal)ColchicineOxadiazoleStereochemistryBinding siteCombinatorial chemistryBiochemistryOrganic chemistryInternal medicineNursingMedicineSynthesis and biological activitySynthesis and Biological EvaluationQuinazolinone synthesis and applications
Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and SAR studies | Litcius