Rhodium(III)‐Catalyzed Alkylation of 2‐Arylquinazolin‐4(3H)‐ones with Cyclopropanols by Directing C‐H Activation and Ring Opening at Ambient Temperature
Mu‐Wang Chen, Minhao Lou, Zhihong Deng, Qin Yang, Yiyuan Peng
Abstract
Abstract An efficient method was developed for the alkylation of 2‐arylquinazolin‐4(3H)‐ones with cyclopropanols. The desired products β ‐aryl ketones bearing the quinazolin‐4(3H)‐one scaffold were synthesized by Rh(III)‐catalyzed C−H activation of arenes and C−C cleavage of cyclopropanols. This method has a wide range of benzyl/phenyl substrate applicability and provides a theoretical guidance for our research to study quinazoline compounds.
Topics & Concepts
ChemistryRhodiumAlkylationCatalysisArylQuinazolineRing (chemistry)Cleavage (geology)Substrate (aquarium)Medicinal chemistryCombinatorial chemistryOrganic chemistryOceanographyGeologyEngineeringFracture (geology)AlkylGeotechnical engineeringQuinazolinone synthesis and applicationsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis