Coarse-grained MD simulations reveal beta-amyloid fibrils of various sizes bind to interfacial liquid-ordered and liquid-disordered regions in phase separated lipid rafts with diverse membrane-bound conformational states
Sara Y. Cheng, Yiyi Cao, Marzieh Rouzbehani, Kwan Hon Cheng
Topics & Concepts
ChemistryLipid raftFibrilRaftMembraneTrimerDimerBiophysicsCrystallographyPhospholipidLipid bilayerAmyloid (mycology)BiochemistryPolymerBiologyInorganic chemistryCopolymerOrganic chemistryLipid Membrane Structure and BehaviorAlzheimer's disease research and treatmentsSupramolecular Self-Assembly in Materials