Hydrophilic polymer driven crystallization self-assembly: an inflammatory multi-drug combination nanosystem against Alzheimer’s disease
Haodong Hu, Jinna Wang, Jian Ren, Xinpo Li, Bo Zhang, Zhengang Lv, Fengying Dai
Abstract
, CEL/IBU (mixture of CEL and IBU) and CEL/TEL (mixture of CEL and TEL) suppress the activation of glia and reduce the levels of inflammatory mediators through eliminating cyclooxygenase 2 (COX-2) signals. The CEL/TEL combination nanosystem is better at correcting neuroinflammation and improving the spatial memory ability of a senescence-accelerated mouse prone 8 model (SAMP8). We consider that the inflammation responsive combination nanosystem provides a new potential treatment for AD clinical patients.
Topics & Concepts
MicelleBoronic acidIbuprofenIn vivoDrugChemistryDrug deliveryMaterials scienceCombinatorial chemistryPharmacologyChemical engineeringBiophysicsNanotechnologyOrganic chemistryAqueous solutionMedicineEngineeringBiologyBiotechnologyNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsSupramolecular Self-Assembly in Materials