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Single-cell RNA sequencing reveals S100a9<sup>hi</sup> macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion

Shichun Shen, Meng Zhang, Xiaohe Wang, Qiaoling Liu, Huimin Su, Bingyi Sun, Zhiqing Guo, Beiduo Tian, Hong Gan, Gong Chen, Likun Ma

2024Theranostics64 citationsDOIOpen Access PDF

Abstract

macrophages are a promising therapeutic target for managing the transition from inflammation to fibrosis after MIR.

Topics & Concepts

InflammationS100A9FibrosisMacrophageMyofibroblastCancer researchProinflammatory cytokineMonocyteCardiac fibrosisCell biologyImmunologyMedicineChemistryPathologyBiologyBiochemistryIn vitroCardiac Fibrosis and RemodelingSignaling Pathways in DiseaseCardiac Ischemia and Reperfusion
Single-cell RNA sequencing reveals S100a9<sup>hi</sup> macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion | Litcius