<i>In Vitro</i> and Intracellular Activities of Omadacycline against Legionella pneumophila
Jacques Dubois, Maïtée Dubois, Jean-François Martel
Abstract
Omadacycline is an aminomethylcycline antibiotic with in vitro activity against pathogens causing community-acquired bacterial pneumonia (CABP). This study investigated the activity of omadacycline against Legionella pneumophila strains isolated between 1995 and 2014 from nosocomial or community-acquired respiratory infections. Omadacycline exhibited extracellular activity similar to comparator antibiotics; intracellular penetrance was found by day 3 of omadacycline exposure.
Topics & Concepts
Legionella pneumophilaLegionellaLegionnaires' diseaseMicrobiologyIn vitroIntracellularChemistryBiologyBacteriaBiochemistryGeneticsLegionella and Acanthamoeba researchNeutrophil, Myeloperoxidase and Oxidative MechanismsAntibiotic Resistance in Bacteria