N-Heterocyclic Carbene-Catalyzed Asymmetric Synthesis of Cyclopentenones
Zhizhou Chen, Xiangwen Kong, Shengtong Niu, Shuang Yang, Jinggong Liu, Bolai Chen, Benlong Luo, Changyu Zhou, Chenglin Ding, Xinqiang Fang
Abstract
N-Heterocyclic carbene-catalyzed asymmetric construction of cyclopentenones using enals and α-diketones is achieved, furnishing a series of highly functionalized cyclopentenones in a highly diastereo- and enantioselective manner. The protocol tolerates substrates with both aromatic and aliphatic groups, and further transformations of the products delivered a range of value-added molecules.
Topics & Concepts
CarbeneChemistryEnantioselective synthesisCatalysisCombinatorial chemistryMoleculeOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry MethodsCatalytic Cross-Coupling Reactions