Solubility and permeability enhancement of BCS class IV drug ribociclib through cocrystallization
M. K. Chaitanya Mannava, Abhijit Garai, Manish Kumar Bommaka, K. Anand Solomon, Ashwini Nangia
Abstract
Cocrystallization improves the solubility and permeability of BCS class IV anticancer drug ribociclib as a cocrystal with resorcinol and as a salt hydrate with vanillic acid.
Topics & Concepts
SolubilityCocrystalHydrateVanillic acidChemistrySalt (chemistry)Materials scienceOrganic chemistryHydrogen bondMoleculeSynthesis and bioactivity of alkaloidsSynthesis and Reactivity of HeterocyclesNonlinear Optical Materials Research