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Acute O <sub>2</sub> sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors

Alejandro Moreno‐Domínguez, Patricia Ortega‐Sáenz, Lin Gao, Olaia Colinas, Paula García‐Flores, Victoria Bonilla, Julián Aragonés, Maik Hüttemann, Lawrence I. Grossman, Norbert Weißmann, Natascha Sommer, José López‐Barneo

2020Science Signaling94 citationsDOI

Abstract

regulation of breathing, reveal an unanticipated role of HIF2α, and link acute and chronic adaptive responses to hypoxia.

Topics & Concepts

Carotid bodyHypoxia (environmental)ChemoreceptorCytochrome c oxidaseGene expressionBiologyCell biologyGeneEnzymeMedicineInternal medicineEndocrinologyChemistryCardiologyMolecular biologyBiochemistryOxygenCarotid arteriesReceptorOrganic chemistryNeuroscience of respiration and sleepHigh Altitude and HypoxiaCancer, Hypoxia, and Metabolism
Acute O <sub>2</sub> sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors | Litcius