Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice
Takayuki Ozawa, Masato Morikawa, Yasuyuki Morishita, Kazuki Ogikubo, Fumiko Itoh, Daizo Koinuma, Per‐Åke Nygren, Kohei Miyazono
Abstract
. Our results indicate that the monovalent FSTL3-based therapy overcomes the difficulties of current anti-GDF8 therapies.
Topics & Concepts
FollistatinMyostatinTransforming growth factorIn vivoGlycationEndogenyChemistryFusion proteinCell biologyMuscle hypertrophyBiologyReceptorRecombinant DNAInternal medicineEndocrinologyMedicineBiochemistryGeneticsGeneMuscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition