Light-assisted therapy for biofilm infected micro-arc oxidation TiO <sub>2</sub> coating on bone implants
Xiang Han, Guannan Zhang, Maozhou Chai, Xiangyu Zhang
Abstract
Abstract Implant-associated infections is a main factor leading to the failure of titanium (Ti) implants. Micro-arc oxidation is a convenient and effective technique to form a biocompatible metal (Ag + , Cu 2+ and Zn 2+ ) ions-doped TiO 2 coatings to combat bacterial infections. However, compared with the sterilization by metal ions, light-triggered antibacterial therapies have accepted more attention due to its higher antibacterial efficiency and security. Although TiO 2 is an excellent photocatalyst, it can be triggered by ultraviolet light due to the wide band gap. Herein, molybdenum disulfide (MoS 2 ) modified TiO 2 coating was fabricated on Ti by a hybrid process of micro-arc oxidation and hydrothermal treatment. The hybrid coating exhibits excellent antibacterial activity under the irradiation of 808 nm near-infrared light because of the synergistic antibacterial effects of reactive oxygen species and hyperthermia, and Staphylococcus aureus ( S. aureus ) biofilm can be eradicated within 15 min both in vivo and in vitro . Furthermore, collagen decorated on the surface of the hybrid coating can improve the proliferation, adhesion and spreading of MC3T3-E1 osteoblasts.