One‐Pot Synthesis of 2,3,6‐Trisubstituted Pyridines by Phosphine‐Catalyzed Annulation of γ‐Vinyl Allenoates with Enamino Esters Followed by DDQ‐Promoted Oxidative Aromatization
Xiaohu Li, Wei Cai, You Huang
Abstract
Abstract A one‐pot strategy for constructing trisubstituted pyridine derivatives had been established via phosphine‐catalyzed annulation and DDQ oxidative aromatization reactions. This protocol provides trisubstituted pyridines from γ‐vinyl allenoates and enamino esters under metal‐free conditions. magnified image
Topics & Concepts
AromatizationChemistryAnnulationPhosphineCatalysisPyridineOxidative phosphorylationOrganic chemistryCombinatorial chemistryMedicinal chemistryBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Characterization of Pyrroles