Aquaporin-driven hydrogen peroxide transport: a case of molecular mimicry?
Darren Wragg, Stefano Leoni, Angela Casini
Abstract
molecule solvation and transport in both directions, highlighting the fundamental role of water nanoconfinement for successful transduction and molecular selection. Overall, the bidirectional nature of the water flux under equilibrium conditions along with the mimicking behavior of hydrogen peroxide during a conductance event introduce a new chemical paradigm never reported so far in any theoretical paper involving any aquaporin isoform.
Topics & Concepts
AquaporinHydrogen peroxideMetadynamicsChemistryBiophysicsWater transportMolecular dynamicsSolvationChemical physicsWater channelMoleculeCell biologyWater flowBiochemistryBiologyComputational chemistryEnvironmental scienceEnvironmental engineeringInletEngineeringMechanical engineeringOrganic chemistryIon Transport and Channel RegulationATP Synthase and ATPases ResearchMitochondrial Function and Pathology