Nickel‐Catalyzed, Regio‐ and Enantioselective Benzylic Alkenylation of Olefins with Alkenyl Bromide
Jiandong Liu, Hegui Gong, Shaolin Zhu
Abstract
A NiH-catalyzed migratory hydroalkenylation reaction of olefins with alkenyl bromides has been developed, affording benzylic alkenylation products with high yields and excellent chemoselectivity. The mild conditions of the reaction preclude olefinic products from undergoing further isomerization or subsequent alkenylation. Catalytic enantioselective hydroalkenylation of styrenes was achieved by using a chiral bisoxazoline ligand.
Topics & Concepts
ChemoselectivityEnantioselective synthesisIsomerizationChemistryCatalysisBromideLigand (biochemistry)Organic chemistryBiochemistryReceptorCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis