High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses
Francisco C. Villafuerte, Tatum S. Simonson, Daniela Bermúdez, Fabiola Lèon‐Velarde
Abstract
Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O 2 -carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).
Topics & Concepts
BiologyEffects of high altitude on humansNeurosciencePsychologyMedicineAnatomyHigh Altitude and HypoxiaAdipose Tissue and MetabolismClimate Change and Health Impacts