Aldehyde as a Traceless Directing Group for Regioselective C–H Alkylation Catalyzed by Rhodium(III) in Air
Si-Qi Chen, Xinran Li, Chao‐Jun Li, Juan Fan, Zhong‐Wen Liu, Xian‐Ying Shi
Abstract
The aromatic aldehyde as a traceless directing group for the regionselective C-H alkylation catalyzed by rhodium(III) under aerobic atmospheric conditions has been developed. The process involves an aldehyde assisted direct addition of C-H bond to unsaturated electrophiles of acrylates or acrylic acids, and the subsequent decarbonylation. A trace amount of water is found to favor the reaction.
Topics & Concepts
ChemistryRhodiumAldehydeElectrophileDecarbonylationRegioselectivityAlkylationCatalysisMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions