Sinapine-enriched rapeseed oils reduced fatty liver formation in high-fat diet-fed C57BL/6J mice
Youdong Li, Jinwei Li, Peirang Cao, Yuanfa Liu
Abstract
< 0.05) by 15.67%, 73.62%, 20.67%, and 31.58%, respectively, compared with that in the HF group. Besides, the addition of sinapine prevented the degeneration of mouse adipocytes and lipid accumulation in the liver. Moreover, this change was achieved by downregulating SREBP-1c and FAS and upregulating PPAR-α and ACOX1 gene expression levels. Our results indicate that sinapine can be used as a prebiotic to enhance the nutritional function of vegetable oils to prevent obesity-related chronic diseases such as NAFLD.
Topics & Concepts
RapeseedChemistryPolyphenolFatty liverEndocrinologyInternal medicineFood scienceObesityBiochemistryBiologyMedicineAntioxidantDiseaseLipid metabolism and biosynthesisFatty Acid Research and HealthLiver Disease Diagnosis and Treatment