Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy
Song Chen, Zhendong Chen, Lixue Lu, Yunpeng Zhao, Ronghui Zhou, Qiong Xie, Yongzhi Shu, Jun Lin, Xufen Yu, Yonghui Wang
Topics & Concepts
Bruton's tyrosine kinaseChemistryIbrutinibbreakpoint cluster regionLinkerTyrosine kinaseSmall moleculeCancer researchBiochemistryPharmacologySignal transductionReceptorImmunologyBiologyLeukemiaOperating systemComputer scienceChronic lymphocytic leukemiaProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways