Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
Horst Lechner, Gustav Oberdorfer
Abstract
Catalytically active non-metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non-natural cofactors are reviewed here. We report the status quo for enzymes harboring organocatalysts as derivatives of natural cofactors or as artificial ones and their application in the asymmetric synthesis of various compounds.
Topics & Concepts
CofactorCatalysisChemistryEnzymeBiocatalysisOrganocatalysisEnzyme catalysisOrganic chemistryCombinatorial chemistryBiochemistryEnantioselective synthesisReaction mechanismCyclopropane Reaction MechanismsMetal-Catalyzed Oxygenation MechanismsEnzyme Catalysis and Immobilization