A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2
Werner C. Albrich, Tarini Shankar Ghosh, Sinéad Ahearn-Ford, Flora Mikaeloff, Nonhlanhla Lunjani, Brian M. Forde, Noémie Suh, Gian‐Reto Kleger, Urs Pietsch, Manuel Frischknecht, Christian Garzoni, Rossella Forlenza, Mary Horgan, Corinna Sadlier, Tommaso Rochat Negro, Jérôme Pugin, Hannah Wozniak, Andreas Cerny, Ujjwal Neogi, Paul W. O’Toole, Liam O’Mahony
Abstract
, short chain fatty acids (SCFAs) and IL-17A. Our study uncovered distinct mechanistic modules that link host and microbiome processes with fatal outcomes to SARS-CoV-2 infection. These features may be useful to identify at risk individuals, but also highlight a role for the microbiome in modifying hyperinflammatory responses to SARS-CoV-2 and other infectious agents.
Topics & Concepts
BiologyImmune systemImmunologyMicrobiomeDiseaseGut floraRuminococcusCoronavirusMedicineBioinformaticsInternal medicineCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)Gut microbiota and healthCOVID-19 Clinical Research StudiesClostridium difficile and Clostridium perfringens research